Tracking the relevant researches of CADD drug development against COVID-19
Rhein is an anthraquinone metabolite of rheinanthrone and senna glycoside is present in many medicinal plants including Rheum palmatum, Cassia tora, Polygonum multiflorum, and Aloe barbadensis. It is known to have hepatoprotective, nephroprotective, anti-cancer, anti-inflammatory, and several other protective effects. [DrugBank]
Oxysterols receptor LXR-alpha (Humans); Oxysterols receptor LXR-beta (Humans); Arylamine N-acetyltransferase (Helicobacter pylori); Arachidonate 5-lipoxygenase (Humans) [DrugBank]
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Rhein in the SMILES input box.
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Rhein to perform blind docking.