Tracking the relevant researches of CADD drug development against COVID-19
A long-acting injectable antipsychotic agent used for chronic schizophrenia. [DrugBank]
Dopamine D2 receptor (Humans); 5-hydroxytryptamine receptor 2A (Humans); Voltage-dependent calcium channel gamma-1 subunit (Humans) [DrugBank]
Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia. Fluspirilene does not differ greatly from other depot antipsychotics (fluphenazine decanoate, fluphenazine enathate, perphenazine onanthat, pipotiazine undecylenate) with respect to treatment efficacy, response or tolerability. Outcomes suggest that fluspirilene does not differ significantly from oral antipsychotics or in different weekly regimens, although much cannot be inferred because of the shortage of trials. [DrugBank]
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Fluspirilene in the SMILES input box.
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Fluspirilene to perform blind docking.