Tracking the relevant researches of CADD drug development against COVID-19
An anthracenedione-derived antineoplastic agent. [DrugBank]
DNA (Humans); DNA topoisomerase 2-alpha (Humans) [DrugBank]
Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. [DrugBank]
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Mitoxantrone in the SMILES input box.
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Mitoxantrone to perform blind docking.