Tracking the relevant researches of CADD drug development against COVID-19
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungusBeauveria nivea.Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novartis (previously known as Sandoz). [DrugBank]
Calcium signal-modulating cyclophilin ligand (Humans); Calcineurin subunit B type 2 (Humans); Peptidyl-prolyl cis-trans isomerase A (Humans); Peptidyl-prolyl cis-trans isomerase F, mitochondrial (Humans) [DrugBank]
Cyclosporine exerts potent immunosuppressive actions on T cells, thereby prolonging survival following organ and bone marrow transplants.23 This drug prevents and controls serious immune-mediated reactions including allograft rejection, graft versus host disease, and inflammatory autoimmune disease.23 [DrugBank]
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Cyclosporine A in the SMILES input box.
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Cyclosporine A to perform blind docking.