Tracking the relevant researches of CADD drug development against COVID-19
Terbutaline was first synthesized in 1966and described in the literature in the late 1960s and early 1970s.It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.Terbutaline was granted FDA approval on 25 March 1974. [DrugBank]
Beta-2 adrenergic receptor (Humans); Beta-3 adrenergic receptor (Humans); Beta-1 adrenergic receptor (Humans) [DrugBank]
Terbutaline is a beta-2 adrenergic receptor agonist indicated to treat reversibly bronchospasm in asthmatic patients with bronchitis and emphysema.16,17 It has a short duration as the inhaled form is taken up to three times daily, and the therapeutic window is wide.16,17 [DrugBank]
Tips: Click on the link to jump to the 'SwissTargetPrediction' webserver. Select the species of 'Homo sapiens', and then paste the SMILES of Terbutaline in the SMILES input box.
Tips: Click on the link to jump to the 'CB-Dock' webserver. Upload the structure file of target predicted by 'SwissTargetPrediction' and the 2D/3D structure file of Terbutaline to perform blind docking.